Browsing by Author "Sarac, Bulent"
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Changes in spontaneous contractions of rat ileum by aflatoxin in vitro
Gursoy, Nevcihan; Sarac, Bulent; Durmus, Nedim; Parlak, Ahmet; Yildirim, Sahin; Kaya, Tijen; Bagcivan, Ihsan (PERGAMON-ELSEVIER SCIENCE LTD, 2008)Aflatoxins are a group of mycotoxins produced by toxigenic strains of Aspergillus flavus, Aspergillus parasiticus and Aspergillus nomius as secondary metabolites. Most of the studies on the aflatoxins have focused mainly ... -
Comparative Relaxant Effects of Ataciguat and Zaprinast on Sheep Sphincter of Oddi
Cakmak, Erol; Yonem, Ozlem; Sarac, Bulent; Parlak, Mesut; Celik, Cumali; Ataseven, Hilmi; Bagcivan, Ihsan (GALENOS YAYINCILIK, 2016)Background: Relaxing the sphincter of Oddi (SO) is an important process during endoscopic retrograde cholangiopancreatography (ERCP) procedures. This issue suggests that the easier the sphincterotomy and cannulation, the ... -
Effect of hypothyroidism on the NO/cGMP pathway of corpus cavernosum in rabbits
Kilicarslan, Hakan; Bagcivan, Ihsan; Yildirim, M. Kemal; Sarac, Bulent; Kaya, Tijen (BLACKWELL PUBLISHING, 2006)Introduction. The incidence of hormonal dysfunction as a cause of impotence remains controversial. However, several recent studies have reported evidence of hormonal abnormalities in 25-35% of impotent men. Hypothyroidism ... -
Effects of Cannabinoid Agonists on Sheep Sphincter of Oddi in vitro
Sarac, Bulent; Durmus, Nedim; Altun, Ahmet; Turan, Mustafa; Kaya, Tijen; Sencan, Mehmet; Bagcivan, Ihsan (ELSEVIER SCIENCE BV, 2011)Background/Aims: According to recent studies, the endocannabinoid system plays an important role in both physiological and pathophysiological situations. The purpose of the present study was to investigate the effects of ... -
Investigating the effects of the Rho-kinase enzyme inhibitors AS1892802 and fasudil hydrochloride on the contractions of isolated pregnant rat myometrium
Ergul, Merve; Turgut, Nergiz H.; Sarac, Bulent; Altun, Ahmet; Yildirim, Sahin; Bagcivan, Ihsan (ELSEVIER SCIENCE BV, 2016)Objectives: Rho-kinases (ROCKs), are one of the dynamic structures of the actin cytoskeleton and they mediate different biological processes, including regulation of calcium sensitivity of smooth muscle contraction. The ... -
Investigation of acute effects of aflatoxin on rat proximal and distal colon spontaneous contractions
Gursoy, Nevcihan; Durmus, Nedim; Bagcivan, Ihsan; Sarac, Bulent; Parlak, Ahmet; Yildirim, Sahin; Kaya, Tijen (PERGAMON-ELSEVIER SCIENCE LTD, 2008)Aflatoxins are one of the most potent toxic, mutagenic, teratogenic, cancerogenic, and immunosuppresive substances that naturally Occurring contaminants of food. There are some studies in various animal species that have ... -
Investigation of Antitumor Effects of Sorafenib and Lapatinib Alone and in Combination on MCF-7 Breast Cancer Cells
Kacan, Turgut; Altun, Ahmet; Altun, Gulsah Gultekin; Kacan, Selen Baloglu; Sarac, Bulent; Seker, Mehmet Metin; Bahceci, Aykut; Babacan, Nalan (ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2014)Background: Breast cancer evolution and tumor progression are controlled by complex interactions between steroid receptors and growth factor receptor signaling. Aberrant growth factor receptor signaling can augment or ... -
Investigation of Relaxant Effects of New Agents Affecting Nitric Oxide/Cyclic Guanosine Monophosphate Pathway on Sheep Oddi Sphincter
Sarac, Bulent; Durmus, Nedim; Bagcivan, Ihsan; Altun, Ahmet; Turan, Mustafa; Sencan, Mehmet (LIPPINCOTT WILLIAMS & WILKINS, 2010)Objectives: Nitric oxide (NO) is a potent nonadrenergic, noncholinergic mediator of gastrointestinal smooth muscle. We aimed to investigate the effects of new NO/cyclic guanosine monophosphate (cGMP) pathway-affecting ... -
Investigation of the Relaxant Effect Mechanism of Ketamine on Normal and Ovalbumin-Induced Trachea in Guinea Pigs
Sarac, Bulent; Altun, Ahmet; Yildirim, Sahin; Yildirim, Mustafa Kemal; Temiz, Tijen Kaya; Bagcivan, Ihsan; Sencan, Mehmet (ORTADOGU AD PRES & PUBL CO, 2011)Objective: The aim of this study was to investigate of effects and the possible mechanisms of effects of ketamine on the isolated trachea preparations from control and ovalbumin sensitized guinea pigs. Material and Methods: ... -
Investigation of the vasorelaxant effects of moxonidine and its relaxation mechanism on the human radial artery when used as a coronary bypass graft
Sarac, Bulent; Korkmaz, Ozge; Altun, Ahmet; Bagcivan, Ihsan; Goksel, Sabahattin; Yildirim, Sahin; Berkan, Ocal (OXFORD UNIV PRESS, 2015)In both low- and high-risk patients undergoing coronary artery bypass grafting, the internal mammary artery is the first choice of arterial graft, and the second choice is the radial artery (RA). Unfortunately, RA spasms ... -
Labetalol, nebivolol, and propranolol relax human radial artery used as coronary bypass graft
Korkmaz, Ozge; Sarac, Bulent; Goksel, Sabahattin; Yildirim, Sahin; Berkan, Ocal; Bagcivan, Ihsan (MOSBY-ELSEVIER, 2015)Objective: Beta-blockers are a heterogeneous class of agents that are used in the treatment of many cardiovascular diseases, especially hypertension and atherosclerosis, and that are commonly prescribed after cardiac ... -
Lack of nitrate tolerance in isosorbid dinitrate- and sodium nitroprusside-induced relaxation of rabbit internal anal sphincter
Koyuncu, Ayhan; Bagcivan, Ihsan; Sarac, Bulent; Aydin, Cengiz; Yildirim, Sahin; Sarioglu, Yusuf (BAISHIDENG PUBL GRP CO LTD, 2008)AIM: To investigate the tolerance development against the relaxant effect of nitric oxide donating drug isosorbide dinitrate (ISDN) and sodium nitropruside (SNP) in internal anal sphincter (IAS) smooth muscle. METHODS: ... -
Mechanism of relaxation induced by nicotine in normal and ovalbumin-sensitized guinea-pig trachea
Cevit, Omer; Bagcivan, Ihsan; Sarac, Bulent; Parlak, Ahmet; Durmus, Nedim; Kava, Tiien (ELSEVIER SCIENCE BV, 2007)Nicotine is an irritant molecule in the cigarette that contributes airway hyper-reactivity. The aim of this study was to investigate the mechanism of these effects and effects of nicotine on the isolated trachea preparations ... -
Role of pentoxifylline and iloprost in the prevention of ischemia-reperfusion injury in an experimental model of intestine ischemia-reperfusion in rats
Abakay, Ugur; Soylu, Sinan; Goksel, Sabahattin; Sarac, Bulent; Inan, Zeynep Deniz Sahin; Cakmak, Erol; Korkmaz, Ozge; Kurt, Atilla; Genc, Husnu Cagri (TURKISH ASSOC TRAUMA EMERGENCY SURGERY, 2018)BACKGROUND: Intestinal ischemia-reperfusion (I/R) injury can lead to multiple organ failure and death. The aim of this study was to investigate the effects of pentoxifylline and iloprost administered before reperfusion in ... -
Scavenging effect and antispasmodic activity of the essential oil of Cyclotrichium niveum
Cetinus, Senay Akkus; Goze, Ismihan; Sarac, Bulent; Vural, Nilufer (ELSEVIER SCIENCE BV, 2007)The radical scavenging and the spasmolitic activity of Cyclotrichium niveum essential oil were evaluated in vitro. It showed an IC50 of 1750 mu g/ml on DPPH method and dose dependently (0.1, 0.5 and 1 mg/ml) inhibits the ...